In sub-Sahara Africa, sustainable agricultural sector has been trumpeted as the surest way for livelihood transformation through poverty reduction and ensuring food and nutritional security. Using mango farming as a case study, the paper determines how sustainable agriculture can be achieved by examining the environmental, social and economic impacts of mango farms in a rural setting. Qualitative and quantitative approaches were used to collect primary data from 400 respondents from the Shai Osu-Doku and Yilo-Krobo Districts of the Greater Accra and Eastern Regions respectively of Ghana.